全球蝙蝠巴尔通体流行状况分析

doi:10.17520/biods.2023166

摘要/Abstract

摘要：

巴尔通体是一群全球广泛分布的细菌, 部分种类能引起多种人兽共患病, 宿主包括食肉类、反刍类、啮齿类、灵长类以及海洋中鲸类等哺乳动物。近年来, 世界各地陆续报道蝙蝠能够携带巴尔通体。为了解全球蝙蝠巴尔通体流行情况, 本文系统检索汇总了自2005年以来世界各地对蝙蝠巴尔通体的研究, 较为详细地描述了巴尔通体在蝙蝠这一大类群中的感染状况、宿主分布及遗传进化关系等信息。分析发现, 在31个国家和地区的106种蝙蝠体内检测到巴尔通体, 表明蝙蝠是巴尔通体重要的动物宿主。通过对蝙蝠巴尔通体柠檬酸合酶基因(citrate synthase gene, gltA)序列构建系统发育树, 发现绝大多数蝙蝠巴尔通体与其他宿主来源的巴尔通体亲缘关系较远, 构成蝙蝠巴尔通体独立的类群, 初步揭示这一类巴尔通体具有宿主特异性特征, 提示巴尔通体可能与宿主蝙蝠存在协同进化关系。

关键词: 巴尔通体, 蝙蝠, 细菌, 遗传多样性, 系统发育分析, 协同进化

Abstract

Background & Aim Bartonellae is a worldwide group of bacteria that causes a variety of zoonoses. Their hosts include carnivores, ruminants, rodents, and even mammals such as marine whales. Recently, it has been discovered that Bartonellae can infect bats, one of the important host animals for Bartonellae, worldwide. This review summarizes studies of bat-borne Bartonella worldwide since 2005 to illustrate the prevalence of Bartonellae in bats.

Context & Conclusions Bartonellae has been detected in 106 bat species in 31 countries and regions around the world, indicating that bats are major animal hosts. The feeding habit of bats does not affect whether they can carry Bartonellae, which has been found in bats with multiple feeding habits. The phylogenetic tree based on gltA sequences of bat-borne Bartonella displayed that most bat-borne Bartonella sequences are distant from other host-derived Bartonella and constituted a bat-origin Bartonella group. Bat-borne Bartonella, which has spread with bats worldwide, is host-specific to a certain extent. It is hinted that there is coevolution between Bartonellae and bat hosts.

Key words: Bartonella, bat, bacteria, genetic diversity, phylogenetic analysis, coevolution

李庆多, 栗冬梅 (2023) 全球蝙蝠巴尔通体流行状况分析. 生物多样性, 31, 23166. DOI: 10.17520/biods.2023166.

Qingduo Li, Dongmei Li (2023) Analysis for the prevalence of global bat-borne Bartonella. Biodiversity Science, 31, 23166. DOI: 10.17520/biods.2023166.

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链接本文: https://www.biodiversity-science.net/CN/10.17520/biods.2023166

https://www.biodiversity-science.net/CN/Y2023/V31/I9/23166

图/表 3

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洲和国家(参考文献) Continents and countries studied (References)				感染巴尔通体的蝙蝠 Bats infected with Bartonellae			感染率 Infection rates (%)	调查方法(目标基因) Investigation methods (target genes)
非洲 Africa	南非 South Africa (Dietrich et al, 2016)			韦氏颈囊果蝠 Epomophorus wahlbergi 长翼蝠 Miniopterus natalensis 埃及果蝠 Rousettus aegyptiacus			15.5	PCR (gltA)
	斯威士兰 Swaziland (Dietrich et al, 2016)			非洲凹脸蝠 Nycteris thebaica			2.7	PCR (gltA)
	尼日利亚 Nigeria (Kamani et al, 2014; Bai et al, 2018)			黄毛果蝠 Eidolon helvum Epomophorus sp. Micropterus sp. 埃及果蝠 Rousettus aegyptiacus 菊头蝠属一种 Rhinolophus sp.			12.4-15.5	分离培养 Isolation & culture, PCR (gltA)
	赞比亚 Zambia (Qiu et al, 2020)			埃及果蝠 Rousettus aegyptiacus Hipposideros vittatus			16.7	分离培养 Isolation & culture, PCR (gltA)
	马达加斯加 Madagascar (Brook et al, 2015)			Eidolon dupreanum			23.6	PCR (gltA)
	肯尼亚 Kenya (Kosoy et al, 2010)			南鞘尾蝠 Coleura afra 黄毛果蝠 Eidolon helvum 康氏蹄蝠 Hipposideros commersoni 长翼蝠属一种 Miniopterus sp. 埃及果蝠 Rousettus aegyptiacus 波斯叶鼻蝠 Triaenops persicus			32.0	分离培养 Isolation & culture, PCR (gltA)
欧洲 Europe	芬兰 Finland (Veikkolainen et al, 2014; Lilley et al, 2015)			水鼠耳蝠 Myotis daubentonii 圆形叶口蝠 Desmodus rotundus 北棕蝠 Eptesicus nilssonii			33.3-37.1	PCR (gltA, rpoB)
	英国 Britain (Concannon et al, 2005)			翼蝠属一种 Pipistrellus sp.			8.3	PCR (gltA)
	法国 France (Stuckey et al, 2017)			水鼠耳蝠 Myotis daubentonii 须鼠耳蝠 Myotis mystacinus 褐山蝠 Nyctalus noctula 纳氏伏翼蝠 Pipistrellus nathusii			10.1	PCR (gltA)
	意大利 Italy (Szentiványi et al, 2020)			普通长翼蝠 Miniopterus schreibersii			25.0	PCR (gltA)
	匈牙利 Hungary (Szentiványi et al, 2020)			普通长翼蝠 Miniopterus schreibersii			33.3	PCR (gltA)
	波兰 Poland (Szubert-Kruszyńska et al, 2019)			大鼠耳蝠 Myotis myotis			25.4	PCR (gltA)
	西班牙 Spain (Stuckey et al, 2017)			未鉴定 Unidentified			3.8	PCR (gltA)
亚洲 Asia	马来西亚 Malaysia (Hou et al, 2018)			小狐蝠 Pteropus hypomelanus			6.7	分离培养 Isolation & culture, PCR (gltA)
	日本 Japan (Nabeshima et al, 2020, 2023)			亚洲长翼蝠 Miniopterus fuliginosus 北棕蝠 Eptesicus nilssonii			24.0-26.0	分离培养 Isolation & culture, PCR (gltA)
	中国 China (Han et al, 2017, 2022; Li et al, 2021; Lin et al, 2012)			普通长翼蝠 Miniopterus schreibersii 毛腿鼠耳蝠 Myotis fimbriatus 北京鼠耳蝠 Myotis pequinius 大足鼠耳蝠 Myotis ricketti 小菊头蝠 Rhinolophus pusillus 马铁菊头蝠 Rhinolophus ferrumequinum 中菊头蝠 Rhinolophus affinis 棕果蝠 Rousettus leschenaultii 小鼠耳蝠 Myotis davidii 郝氏鼠耳蝠 Myotis adversus			10.3-56.4	PCR (gltA), qPCR (ssrA)
	越南 Vietnam (Anh et al, 2015)			大蹄蝠 Hipposideros armiger Hipposideros larvatui 印度假吸血蝠 Megaderma lyra 马来假吸血蝠 Megaderma spasma 泰国无尾果蝠 Megaerops niphanae 大角菊头蝠 Rhinolophus acuminatus Rhinolophus chaseli 中华菊头蝠 Rhinolophus sinicus			35.0	PCR (gltA)
	泰国 Thailand (Mckee et al, 2017; Poofery et al, 2022)	无尾长鼻蝠 Anoura geoffroyi 中蹄蝠 Hipposideros larvatus 黑髯墓蝠 Taphozous melanopogon 圆形叶口蝠 Desmodus rotundus 大耳蹄蝠 Hipposideros fulvus 大蹄蝠 Hipposideros armiger Craseonycteris thonglongyai Rhinolophus coelophyllus Hipposideros kunzi Hipposideros gentilis 喜山鼠耳蝠 Myotis muricola 小蹄蝠 Hipposideros cineraceus 马来假吸血蝠 Megaderma spasma 马来菊头蝠 Rhinolophus malayanus 皮氏菊头蝠 Rhinolophus pearsonii 高颅鼠耳蝠 Myotis siligorensis			25.5-36.6			分离培养 Isolation & culture, PCR (gltA, 16S rRNA gene)
	格鲁吉亚 Georgia (Bai et al, 2017; Urushadze et al, 2017)	棕蝠 Eptesicus serotinus 普通长翼蝠 Miniopterus schreibersii 尖耳鼠耳蝠 Myotis blythii 佐氏鼠耳蝠 Myotis emarginatus Pipistrellus pygmaeus 地中海菊头蝠 Rhinolophus euryale 马铁菊头蝠 Rhinolophus ferrumequinum			35.3-49.5			PCR (ITS (16S-23S internal transcribed spacer locus), gltA)
美洲 America	美国 United States of America (Lilley et al, 2017)	灰鼠耳蝠 Myotis grisescens 小棕蝠 Myotis lucifugus			9.8			PCR (gltA)
	圣基茨和尼维斯 Saint Kitts and Nevis (Reeves et al, 2016)	牙买加果蝠 Artibeus jamaicensis Artibeus fimbriatus 艾氏短尾叶鼻蝠 Carollia castanea			36.9			PCR (gltA)
	哥斯达黎加 Costa Rica (Judson et al, 2015; Mitchell et al, 2022)	Micronycteris microtus Myotis keaysei Chaerephon plicatus Artibeus obscurus 大食果蝠 Artibeus lituratus Platyrrhinus vittatus Vampyressa thyone 昭短尾叶鼻蝠 Carollia perspicillata 毛足黄肩蝠 Sturnira mordax 苍白矛吻蝠 Phyllostomus discolor 美洲林蝠 Ardops nichollsi 黄肩蝠 Sturnira lilium			10.7-33.3			PCR (gltA)
	危地马拉 Guatemala (Bai, 2011; Wray et al, 2016)	中美果蝠 Artibeus toltecus 昭短尾叶鼻蝠 Carollia perspicillata 圆形叶口蝠 Desmodus rotundus 鼩形长舌蝠 Glossophaga soricina 美洲大耳蝠 Micronycteris microtis 苍白矛吻蝠 Phyllostomus discolor 裸背蝠 Pteronotus davyi 黄肩蝠 Sturnira lilium			33.1-39.3			PCR (gltA)
	墨西哥 Mexico (Chomel et al, 2017)	牙买加果蝠 Artibeus jamaicensis 襞兜翼蝠 Balantiopteryx plicata 圆形叶口蝠 Desmodus rotundus 红斑裸背蝠 Pteronotus parnellii 黄肩蝠属一种 Sturnira sp.			22.7			PCR (gltA)
	秘鲁 Peru (Bai et al, 2012; Becker et al, 2018)	Artibeus obscurus 扁吻美洲果蝠 Artibeus planirostris 短尾叶鼻蝠 Carollia brevicauda 昭短尾叶鼻蝠 Carollia perspicillata 圆形叶口蝠 Desmodus rotundus 鼩形长舌蝠 Glossophaga soricina 鼠耳蝠属一种 Myotis sp. 苍白矛吻蝠 Phyllostomus discolor 矛吻蝠 Phyllostomus hastatus			24.1-67.3			PCR (gltA)
			黄肩蝠 Sturnira lilium Vampyriscus bidens
	法属圭亚那 French Guiana (Davoust et al, 2016)		垂耳真蝠 Eumops auripendulus Noctilio albiventris 红斑裸背蝠 Pteronotus parnellii			13.6		PCR (gltA)
	伯利兹 Belize (Becker et al, 2018)		圆形叶口蝠 Desmodus rotundus			45.0		PCR (gltA)
	巴西 Brazil (Ikeda et al, 2017, 2020; Ferreira et al, 2018; André et al, 2019; Gon?alves-Oliveira et al, 2020)		昭短尾叶鼻蝠 Carollia perspicillata 牙买加果蝠 Artibeus jamaicensis 小叶吻蝠 Rhinophylla pumilio 狭叶蝠 Brachyphylla cavernarum 毛腿吸血蝠 Diphylla ecaudata 黄肩蝠 Sturnira lilium 大蹄蝠 Hipposideros armiger 大食果蝠 Artibeus lituratus 苍白矛吻蝠 Phyllostomus discolor 扁吻美洲果蝠 Artibeus planirostris Platyrrhinus lineatus Natalus espiritosantensis 鼩形长舌蝠 Glossophaga soricina Carollia sowelii 圆形叶口蝠 Desmodus rotundus			4.3-24.5		PCR (gltA, nuoG (NADH dehydrogenase gamma subunit gene)), qPCR (ITS)
	阿根廷 Argentina (Cicuttin et al, 2017)		巴西犬吻蝠 Tadarida brasiliensis			4.9		PCR (gltA)
	波多黎各 Puerto Rico (Olival et al, 2015)		牙买加果蝠 Artibeus jamaicensis 狭叶蝠 Brachyphylla cavernarum 牙买加长舌蝠 Monophyllus redmani			17.6		PCR (gltA)
	智利 Chile (Müller et al, 2020)		智利鼠耳蝠 Myotis chiloensis Histiotus montanus Histiotus macrotus 巴西犬吻蝠 Tadarida brasiliensis			38.1		PCR (gltA)

洲和国家(参考文献) Continents and countries studied (References)				感染巴尔通体的蝙蝠 Bats infected with Bartonellae			感染率 Infection rates (%)	调查方法(目标基因) Investigation methods (target genes)
非洲 Africa	南非 South Africa (Dietrich et al, 2016)			韦氏颈囊果蝠 Epomophorus wahlbergi 长翼蝠 Miniopterus natalensis 埃及果蝠 Rousettus aegyptiacus			15.5	PCR (gltA)
	斯威士兰 Swaziland (Dietrich et al, 2016)			非洲凹脸蝠 Nycteris thebaica			2.7	PCR (gltA)
	尼日利亚 Nigeria (Kamani et al, 2014; Bai et al, 2018)			黄毛果蝠 Eidolon helvum Epomophorus sp. Micropterus sp. 埃及果蝠 Rousettus aegyptiacus 菊头蝠属一种 Rhinolophus sp.			12.4-15.5	分离培养 Isolation & culture, PCR (gltA)
	赞比亚 Zambia (Qiu et al, 2020)			埃及果蝠 Rousettus aegyptiacus Hipposideros vittatus			16.7	分离培养 Isolation & culture, PCR (gltA)
	马达加斯加 Madagascar (Brook et al, 2015)			Eidolon dupreanum			23.6	PCR (gltA)
	肯尼亚 Kenya (Kosoy et al, 2010)			南鞘尾蝠 Coleura afra 黄毛果蝠 Eidolon helvum 康氏蹄蝠 Hipposideros commersoni 长翼蝠属一种 Miniopterus sp. 埃及果蝠 Rousettus aegyptiacus 波斯叶鼻蝠 Triaenops persicus			32.0	分离培养 Isolation & culture, PCR (gltA)
欧洲 Europe	芬兰 Finland (Veikkolainen et al, 2014; Lilley et al, 2015)			水鼠耳蝠 Myotis daubentonii 圆形叶口蝠 Desmodus rotundus 北棕蝠 Eptesicus nilssonii			33.3-37.1	PCR (gltA, rpoB)
	英国 Britain (Concannon et al, 2005)			翼蝠属一种 Pipistrellus sp.			8.3	PCR (gltA)
	法国 France (Stuckey et al, 2017)			水鼠耳蝠 Myotis daubentonii 须鼠耳蝠 Myotis mystacinus 褐山蝠 Nyctalus noctula 纳氏伏翼蝠 Pipistrellus nathusii			10.1	PCR (gltA)
	意大利 Italy (Szentiványi et al, 2020)			普通长翼蝠 Miniopterus schreibersii			25.0	PCR (gltA)
	匈牙利 Hungary (Szentiványi et al, 2020)			普通长翼蝠 Miniopterus schreibersii			33.3	PCR (gltA)
	波兰 Poland (Szubert-Kruszyńska et al, 2019)			大鼠耳蝠 Myotis myotis			25.4	PCR (gltA)
	西班牙 Spain (Stuckey et al, 2017)			未鉴定 Unidentified			3.8	PCR (gltA)
亚洲 Asia	马来西亚 Malaysia (Hou et al, 2018)			小狐蝠 Pteropus hypomelanus			6.7	分离培养 Isolation & culture, PCR (gltA)
	日本 Japan (Nabeshima et al, 2020, 2023)			亚洲长翼蝠 Miniopterus fuliginosus 北棕蝠 Eptesicus nilssonii			24.0-26.0	分离培养 Isolation & culture, PCR (gltA)
	中国 China (Han et al, 2017, 2022; Li et al, 2021; Lin et al, 2012)			普通长翼蝠 Miniopterus schreibersii 毛腿鼠耳蝠 Myotis fimbriatus 北京鼠耳蝠 Myotis pequinius 大足鼠耳蝠 Myotis ricketti 小菊头蝠 Rhinolophus pusillus 马铁菊头蝠 Rhinolophus ferrumequinum 中菊头蝠 Rhinolophus affinis 棕果蝠 Rousettus leschenaultii 小鼠耳蝠 Myotis davidii 郝氏鼠耳蝠 Myotis adversus			10.3-56.4	PCR (gltA), qPCR (ssrA)
	越南 Vietnam (Anh et al, 2015)			大蹄蝠 Hipposideros armiger Hipposideros larvatui 印度假吸血蝠 Megaderma lyra 马来假吸血蝠 Megaderma spasma 泰国无尾果蝠 Megaerops niphanae 大角菊头蝠 Rhinolophus acuminatus Rhinolophus chaseli 中华菊头蝠 Rhinolophus sinicus			35.0	PCR (gltA)
	泰国 Thailand (Mckee et al, 2017; Poofery et al, 2022)	无尾长鼻蝠 Anoura geoffroyi 中蹄蝠 Hipposideros larvatus 黑髯墓蝠 Taphozous melanopogon 圆形叶口蝠 Desmodus rotundus 大耳蹄蝠 Hipposideros fulvus 大蹄蝠 Hipposideros armiger Craseonycteris thonglongyai Rhinolophus coelophyllus Hipposideros kunzi Hipposideros gentilis 喜山鼠耳蝠 Myotis muricola 小蹄蝠 Hipposideros cineraceus 马来假吸血蝠 Megaderma spasma 马来菊头蝠 Rhinolophus malayanus 皮氏菊头蝠 Rhinolophus pearsonii 高颅鼠耳蝠 Myotis siligorensis			25.5-36.6			分离培养 Isolation & culture, PCR (gltA, 16S rRNA gene)
	格鲁吉亚 Georgia (Bai et al, 2017; Urushadze et al, 2017)	棕蝠 Eptesicus serotinus 普通长翼蝠 Miniopterus schreibersii 尖耳鼠耳蝠 Myotis blythii 佐氏鼠耳蝠 Myotis emarginatus Pipistrellus pygmaeus 地中海菊头蝠 Rhinolophus euryale 马铁菊头蝠 Rhinolophus ferrumequinum			35.3-49.5			PCR (ITS (16S-23S internal transcribed spacer locus), gltA)
美洲 America	美国 United States of America (Lilley et al, 2017)	灰鼠耳蝠 Myotis grisescens 小棕蝠 Myotis lucifugus			9.8			PCR (gltA)
	圣基茨和尼维斯 Saint Kitts and Nevis (Reeves et al, 2016)	牙买加果蝠 Artibeus jamaicensis Artibeus fimbriatus 艾氏短尾叶鼻蝠 Carollia castanea			36.9			PCR (gltA)
	哥斯达黎加 Costa Rica (Judson et al, 2015; Mitchell et al, 2022)	Micronycteris microtus Myotis keaysei Chaerephon plicatus Artibeus obscurus 大食果蝠 Artibeus lituratus Platyrrhinus vittatus Vampyressa thyone 昭短尾叶鼻蝠 Carollia perspicillata 毛足黄肩蝠 Sturnira mordax 苍白矛吻蝠 Phyllostomus discolor 美洲林蝠 Ardops nichollsi 黄肩蝠 Sturnira lilium			10.7-33.3			PCR (gltA)
	危地马拉 Guatemala (Bai, 2011; Wray et al, 2016)	中美果蝠 Artibeus toltecus 昭短尾叶鼻蝠 Carollia perspicillata 圆形叶口蝠 Desmodus rotundus 鼩形长舌蝠 Glossophaga soricina 美洲大耳蝠 Micronycteris microtis 苍白矛吻蝠 Phyllostomus discolor 裸背蝠 Pteronotus davyi 黄肩蝠 Sturnira lilium			33.1-39.3			PCR (gltA)
	墨西哥 Mexico (Chomel et al, 2017)	牙买加果蝠 Artibeus jamaicensis 襞兜翼蝠 Balantiopteryx plicata 圆形叶口蝠 Desmodus rotundus 红斑裸背蝠 Pteronotus parnellii 黄肩蝠属一种 Sturnira sp.			22.7			PCR (gltA)
	秘鲁 Peru (Bai et al, 2012; Becker et al, 2018)	Artibeus obscurus 扁吻美洲果蝠 Artibeus planirostris 短尾叶鼻蝠 Carollia brevicauda 昭短尾叶鼻蝠 Carollia perspicillata 圆形叶口蝠 Desmodus rotundus 鼩形长舌蝠 Glossophaga soricina 鼠耳蝠属一种 Myotis sp. 苍白矛吻蝠 Phyllostomus discolor 矛吻蝠 Phyllostomus hastatus			24.1-67.3			PCR (gltA)
			黄肩蝠 Sturnira lilium Vampyriscus bidens
	法属圭亚那 French Guiana (Davoust et al, 2016)		垂耳真蝠 Eumops auripendulus Noctilio albiventris 红斑裸背蝠 Pteronotus parnellii			13.6		PCR (gltA)
	伯利兹 Belize (Becker et al, 2018)		圆形叶口蝠 Desmodus rotundus			45.0		PCR (gltA)
	巴西 Brazil (Ikeda et al, 2017, 2020; Ferreira et al, 2018; André et al, 2019; Gon?alves-Oliveira et al, 2020)		昭短尾叶鼻蝠 Carollia perspicillata 牙买加果蝠 Artibeus jamaicensis 小叶吻蝠 Rhinophylla pumilio 狭叶蝠 Brachyphylla cavernarum 毛腿吸血蝠 Diphylla ecaudata 黄肩蝠 Sturnira lilium 大蹄蝠 Hipposideros armiger 大食果蝠 Artibeus lituratus 苍白矛吻蝠 Phyllostomus discolor 扁吻美洲果蝠 Artibeus planirostris Platyrrhinus lineatus Natalus espiritosantensis 鼩形长舌蝠 Glossophaga soricina Carollia sowelii 圆形叶口蝠 Desmodus rotundus			4.3-24.5		PCR (gltA, nuoG (NADH dehydrogenase gamma subunit gene)), qPCR (ITS)
	阿根廷 Argentina (Cicuttin et al, 2017)		巴西犬吻蝠 Tadarida brasiliensis			4.9		PCR (gltA)
	波多黎各 Puerto Rico (Olival et al, 2015)		牙买加果蝠 Artibeus jamaicensis 狭叶蝠 Brachyphylla cavernarum 牙买加长舌蝠 Monophyllus redmani			17.6		PCR (gltA)
	智利 Chile (Müller et al, 2020)		智利鼠耳蝠 Myotis chiloensis Histiotus montanus Histiotus macrotus 巴西犬吻蝠 Tadarida brasiliensis			38.1		PCR (gltA)