It is important to understand and analyze the spatial distribution features and models of crop germplasm resources for the comprehensive collection, effective protection, and efficient utilization of these resources. This paper analyzed these characteristics based on spatial statistical principles and methods with ArcGIS software. Firstly, we did a cold and hot spot analysis of germplasm resources at the national scale to determine discrete regions of Chinese germplasm resources from a qualitative aspect. Then, we analyzed the number and center of gravity characteristics of germplasm resources to determine density and homogeneity of germplasm resources in main crop regions. Finally, we analyzed the bearing distribution characteristics of germplasm resources in different planting partitions to determine the scope of resource distribution, angle, and direction. According to results of cold and hot spot analysis, the northern China plain and a part of the loess plateau region belong to accumulation areas of germplasm resources. The central region of Gansu province, the western part of Sichuan and Xinjiang, and the eastern part of Qinghai belong to a discrete area of germplasm resources. In addition to the blank area of germplasm resources, the rest is part of the random distribution area of germplasm resources. According to quality and gravity center analysis results, the Northwest Oasis region mainly grows wheat, cotton, beets, and grapes, the Qinghai-Tibet Plateau region mainly grows barley, wheat and rape, the Northern plateau region mainly grows small grains and beets, and the Northeast region mainly grows soybeans, spring wheat and beets. These are all located in the northeast and the west of China, and their germplasm resources’ densities are low and uniformities are uneven, which means a small amount of the germplasm resources in the four areas are relatively concentrated in a small area. Not only are the densities of germplasm resources of the 6 regions in southeastern of China large, but also the uniformities are relatively homogeneous. The differences in density and uniformity of germplasm resources between eastern and western China are obvious. According to results of the orientation analysis, the distribution range of germplasm resources in the Northwest Oasis is wheat, cotton, beets, and grapes, while the directional trend of germplasm resources in the South are double crops of rice, tropical crops, and sugarcane. Germplasm resources are distributed as follows in these three regions: in the Northern plateau small grains, beets, Northeast soybean, spring wheat and beets; in the Qinghai-Tibet Plateau highland barley, wheat, and rape, mostly distributed in southern areas; and in the Northwest Oasis wheat, cotton, beets, and grapes found in the north of the region. The distribution of germplasm resources of these 6 southeastern regions has no obvious bias.