Biodiversity Science ›› 2001, Vol. 09 ›› Issue (3): 294-300.doi: 10.17520/biods.2001044
• 论文 •
LIU Qing-Zhen, LI Ling-Yun, QI Yi-Peng, YANG Fu-Hua
RNA viruses are much more than DNA viruses in quantity and species in nature. It can be
divided into many types of viruses according to genomic type. Recently , many researchers indicate that
the ret ron existing in Myxobacteria , which carries only one reverse transcriptase gene , is the possible
ancestor for all kinds of viruses , with the following evolution model : Retron →Ret roposon →Ret ransposon →Ret rovirus →Pararet rovirus →DNA viruses.
It is very different between transcription/ replication of RNA virus and DNA virus genomes in
many aspects. RNA-dependent RNA polymerase is the major catalyst for transcription/ replication.
Initiation sites for RNA virus t ranscription/ replication are specific structures [poly (A) or tRNA] at 3′
terminal region. Internal stop results in transcription but reading through to 5′end resulting in replication. RNA viruses use the following four kinds of templates in transcription/ replication : ( + ) ssRNA
template , ( - ) ssRNA template , ( + ) aRNA template , ( - ) aRNA template.
The mechanism of selective regulation on RNA templates is very complex and the acknowledgements of the regulation mechanism are quite few up to now. Selecting template and the binding of
transcription factors with RNA pol to form replicon are two major regulatory means. Besides promoter
and transcription factors , 5′UTR and 3′UTR also regulate the transcription of RNA viruses.
LIU Qing-Zhen, LI Ling-Yun, QI Yi-Peng, YANG Fu-Hua. Molecular mechanism for transcription and replication of RNA virus. (2001) Biodiv Sci, 09(3), 294-300.
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